Perinatal Dietary Polyunsaturated Fatty Acids in Brain Development, Role in Neurodevelopmental Disorders

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential that provided by dietary intake. Growing evidence suggests PUFAs paramount for brain functions. They constitute crucial elements of cellular membranes, especially in the brain. precursors several metabolites with different effects on inflammation neuron outgrowth. Overall, long-chain accumulate offspring during embryonic post-natal periods. In this review, we discuss how they developing brain, considering maternal supply, polymorphisms genes involved their metabolism, differences linked to gender. We also report mechanisms linking bioavailability transfer from mother embryo through placenta, role development. addition, data potential altered etiologies neurodevelopmental diseases, such as autism, attention deficit hyperactivity disorder, schizophrenia, reviewed.